Enhertu beats standard care in lung cancer trial on key metric

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Go back to Enhertu beats standard care in lung cancer trial on key metric

ENHERTU® (fam-trastuzumab deruxtecan-nxki) demonstrated a median progression-free survival of 14.3 months as 1st-line therapy in patients with HER2-mutant advanced non-small cell lung cancer in DESTI

September 13, 2026 9:55 PM EDT

6-month improvement in median progression-free survival vs. pembrolizumab plus chemotherapy

AstraZeneca and Daiichi Sankyos ENHERTU is the first HER2-directed therapy to delay disease progression over standard of care in a Phase III trial in this setting

WILMINGTON, Del.--(BUSINESS WIRE)-- Positive results from the DESTINY-Lung04 Phase III trial showed AstraZeneca and Daiichi Sankyos ENHERTU® (fam-trastuzumab deruxtecan-nxki) demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) versus global standard of care (platinum-pemetrexed doublet chemotherapy plus pembrolizumab) as a 1st-line treatment of patients with... More