Roth Capital Downgrades Vical (VICL) to Neutral
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Vical (VICL) Genital Herpes Vaccine Phase 1/2 Missed Primary Endpoint
June 22, 2015 4:11 PM EDTVical (NASDAQ: VICL) announced top-line results from an ongoing randomized, double-blind, placebo controlled Phase 1/2 clinical study of its therapeutic genital herpes vaccine, designed to reduce viral shedding and genital herpes lesions in herpes simplex virus type 2 (HSV-2) infected patients. The trial enrolled patients across seven U.S. sites and is evaluating two constructs: a monovalent (gD) vaccine and a bivalent (gD + UL46) vaccine, each formulated with Vical's proprietary Vaxfectin® adjuvant. The top-line analysis compared pre-vaccination measurements for each arm with those taken during the swabbing period in months 2 and 3 following the last vaccine dose.... More
