Notable Holders of (MRUS)
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* Does Not Fully Represent All Holders
| Fund | Title | Shares | % Owned | Source |
|---|---|---|---|---|
| BVF INC/IL | COM | 3,444,420 | N/A | 13F |
| DEERFIELD MANAGEMENT CO /NY | COM | 3,031,938 | N/A | 13F |
| SAMLYN CAPITAL, LLC | COM | 2,837,449 | N/A | 13F |
| COMMODORE CAPITAL LP | COM | 2,732,567 | N/A | 13F |
| Boxer Capital, LLC | COM | 1,900,000 | N/A | 13F |
| VR Adviser, LLC | COM | 1,726,214 | N/A | 13F |
| Medicxi Ventures Management (Jersey) Ltd | COM | 1,600,000 | N/A | 13F |
| BRAIDWELL LP | COM | 1,543,162 | N/A | 13F |
| Fairmount Funds Management LLC | COM | 1,482,405 | N/A | 13F |
| Lynx1 Capital Management LP | COM | 1,152,525 | N/A | 13F |
| DRIEHAUS CAPITAL MANAGEMENT LLC | ADR | 1,136,716 | N/A | 13F |
| RTW INVESTMENTS, LLC | COM | 1,050,893 | N/A | 13F |
| Aquilo Capital Management, LLC | COM | 775,109 | N/A | 13F |
| Frazier Life Sciences Management, L.P. | COM | 746,479 | N/A | 13F |
| Fidelity Investments | COM | 594,556 | N/A | 13F |
| SILVERARC CAPITAL MANAGEMENT, LLC | EQUITIES | 589,255 | N/A | 13F |
| Polar Capital Holdings Plc | COM | 500,000 | N/A | 13F |
| Rock Springs Capital Management LP | COM | 478,531 | N/A | 13F |
| Carmignac Gestion | COM | 454,331 | N/A | 13F |
| DAFNA Capital Management LLC | COM | 384,870 | N/A | 13F |
| Vivo Capital, LLC | Common | 353,600 | N/A | 13F |
| TCG Crossover Management, LLC | COMM | 300,000 | N/A | 13F |
| SPHERA FUNDS MANAGEMENT LTD. | COM | 278,333 | N/A | 13F |
| Ally Bridge Group (NY) LLC | COM | 275,970 | N/A | 13F |
| TWO SIGMA ADVISERS, LLC | COM | 198,000 | N/A | 13F |
| Hudson Bay Capital Management, L.P. | COM | 167,818 | N/A | 13F |
| Schonfeld Strategic Advisors LLC | COM | 162,501 | N/A | 13F |
| Nan Fung Group Holdings Ltd | COM | 151,000 | N/A | 13F |
| Platinum Investment Management Ltd. | COM | 150,238 | N/A | 13F |
| UBS OCONNOR LLC | COM | 147,106 | N/A | 13F |
| Eversept Partners, LLC | COM | 131,226 | N/A | 13F |
| Burrage Capital Management LLC | COM | 130,683 | N/A | 13F |
| VANGUARD GROUP INC | COM | 123,007 | N/A | 13F |
| TWO SIGMA INVESTMENTS LLC | COM | 112,545 | N/A | 13F |
| DEUTSCHE BANK AG\ | COM | 112,317 | N/A | 13F |
| Tri Locum Partners LP | COM | 101,691 | N/A | 13F |
| ALGERT COLDIRON INVESTORS LLC | COM | 99,702 | N/A | 13F |
| ING INVESTMENT MANAGEMENT LLC | COM | 93,975 | N/A | 13F |
| Parkman Healthcare Partners LLC | COM | 67,881 | N/A | 13F |
| Polar Securities Inc. | COM | 66,400 | N/A | 13F |
| PARAMETRIC PORTFOLIO ASSOCIATES | Common Stock | 65,268 | N/A | 13F |
| Swiss National Bank | COM | 64,954 | N/A | 13F |
| Ikarian Capital, LLC | COM | 63,125 | N/A | 13F |
| Bellevue Group AG | COM | 44,500 | N/A | 13F |
| CREDIT SUISSE AG/ | COM | 38,731 | N/A | 13F |
| Bank of New York Mellon CORP | COM | 36,038 | N/A | 13F |
| HighVista Strategies LLC | COM | 34,027 | N/A | 13F |
| GEODE CAPITAL MANAGEMENT LLC | COM | 31,371 | N/A | 13F |
| Marshall Wace LLP | COMMON STOCK | 31,100 | N/A | 13F |
| Alpha DNA Investment Management LLC | COM | 28,817 | N/A | 13F |
| BNP PARIBAS ARBITRAGE, SA | Equity | 28,118 | N/A | 13F |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | COMMON STOCK | 26,486 | N/A | 13F |
| STATE OF WISCONSIN INVESTMENT BOARD | COM | 26,394 | N/A | 13F |
| DekaBank Deutsche Girozentrale | COM | 25,000 | N/A | 13F |
| SANDERS MORRIS HARRIS INC. | COM | 24,870 | N/A | 13F |
| MILLENNIUM MANAGEMENT LLC | COM | 24,312 | N/A | 13F |
| TUDOR INVESTMENT CORP ET AL | Equity | 23,638 | N/A | 13F |
| UBS GLOBAL ASSET MANAGEMENT AMERICAS INC | NON US EQTY | 21,928 | N/A | 13F |
| LEGAL & GENERAL GROUP PLC | COM | 21,414 | N/A | 13F |
| AE Wealth Management LLC | COM | 19,699 | N/A | 13F |
| Mach-1 Financial Group, Inc. | COM | 19,699 | N/A | 13F |
| Allianz Asset Management AG | COM | 18,063 | N/A | 13F |
| Weiss Multi-Strategy Advisers LLC | COM | 16,903 | N/A | 13F |
| RENAISSANCE TECHNOLOGIES LLC | COM | 14,021 | N/A | 13F |
| Cubist Systematic Strategies, LLC | COM | 13,836 | N/A | 13F |
| INNOVIS ASSET MANAGEMENT LLC | COM | 13,299 | N/A | 13F |
| Mitsubishi UFJ Asset Management Co., Ltd. | COM | 12,136 | N/A | 13F |
| BOOTHBAY FUND MANAGEMENT, LLC | COM | 11,523 | N/A | 13F |
| Tower Research Capital LLC | COM | 11,410 | N/A | 13F |
| Verition Fund Management LLC | COM | 10,301 | N/A | 13F |
| Corton Capital Inc. | COM | 9,293 | N/A | 13F |
| Arizona State Retirement System | COM | 8,456 | N/A | 13F |
| TEACHER RETIREMENT SYSTEM OF TEXAS | COM | 8,168 | N/A | 13F |
| Russell Investments Group, Ltd. | Common Stock | 5,710 | N/A | 13F |
| EXCHANGE TRADED CONCEPTS, LLC | COM | 5,419 | N/A | 13F |
| NEW YORK STATE COMMON RETIREMENT FUND | Foreign Stock | 4,477 | N/A | 13F |
| Zurcher Kantonalbank (Zurich Cantonalbank) | COM | 4,235 | N/A | 13F |
| Virtus ETF Advisers LLC | COM | 4,103 | N/A | 13F |
| Coppell Advisory Solutions LLC | COM | 1,732 | N/A | 13F |
| SIGNATUREFD, LLC | COM | 1,139 | N/A | 13F |
| QUADRANT CAPITAL GROUP LLC | COM | 910 | N/A | 13F |
| FourThought Financial, LLC | Stock | 752 | N/A | 13F |
| China Universal Asset Management Co., Ltd. | Common Stock | 610 | N/A | 13F |
| ACADIAN ASSET MANAGEMENT LLC | COM | 541 | N/A | 13F |
| ABSOLUTE INVESTMENT MANAGEMENT LLC | COM | 423 | N/A | 13F |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | COM | 404 | N/A | 13F |
| HealthInvest Partners AB | COM | 286 | N/A | 13F |
| Point72 Middle East FZE | COM | 243 | N/A | 13F |
| Lindbrook Capital, LLC | Stock | 131 | N/A | 13F |
| Goss Wealth Management LLC | Common Stock | 100 | N/A | 13F |
| Washington Trust Advisors, Inc. | COM | 60 | N/A | 13F |
| Parallel Advisors, LLC | Stock | 6 | N/A | 13F |
