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   <title>Spruce Biosciences to Present at Upcoming Investor Conferences in March</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</link>
   <description>
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fsprucebio.com%2F&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d4dbbe0c6efdc7a826517b31902749f9&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at two upcoming investor conferences taking place in March.

&lt;/p&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
Leerink Global Healthcare Conference
&lt;br /&gt;Date and Time: March 9, 2026, at 11:20 a.m. ET
&lt;br /&gt;Format: &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fevent.summitcast.com%2Fview%2FmT9poctHDNthc6b89WqVjf%2Fguest_book%3Fsession_id%3DffE6xjDStYAPC5NnkVMYfx&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Fireside+chat&amp;amp;index=2&amp;amp;md5=ad50f00f11531a22c7db9a4eaa9a2687&quot; shape=&quot;rect&quot;&gt;Fireside chat&lt;/a&gt; and 1x1 meetings
&lt;br /&gt;Location: Miami, FL
&lt;br /&gt;

&lt;/li&gt;
&lt;/ul&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
The Citizens Life Sciences Conference
&lt;br /&gt;Date and Time: March 10, 2026, at 12:30 p.m. ET
&lt;br</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</guid>
   <pubDate>Mon, 02 Mar 2026 16:05:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences to Present at Upcoming Investor Conferences in March</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</link>
   <description>
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fsprucebio.com%2F&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d4dbbe0c6efdc7a826517b31902749f9&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at two upcoming investor conferences taking place in March.

&lt;/p&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
Leerink Global Healthcare Conference
&lt;br /&gt;Date and Time: March 9, 2026, at 11:20 a.m. ET
&lt;br /&gt;Format: &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fevent.summitcast.com%2Fview%2FmT9poctHDNthc6b89WqVjf%2Fguest_book%3Fsession_id%3DffE6xjDStYAPC5NnkVMYfx&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Fireside+chat&amp;amp;index=2&amp;amp;md5=ad50f00f11531a22c7db9a4eaa9a2687&quot; shape=&quot;rect&quot;&gt;Fireside chat&lt;/a&gt; and 1x1 meetings
&lt;br /&gt;Location: Miami, FL
&lt;br /&gt;

&lt;/li&gt;
&lt;/ul&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
The Citizens Life Sciences Conference
&lt;br /&gt;Date and Time: March 10, 2026, at 12:30 p.m. ET
&lt;br</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</guid>
   <pubDate>Mon, 02 Mar 2026 16:05:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences to Present at Upcoming Investor Conferences in March</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</link>
   <description>
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fsprucebio.com%2F&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d4dbbe0c6efdc7a826517b31902749f9&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at two upcoming investor conferences taking place in March.

&lt;/p&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
Leerink Global Healthcare Conference
&lt;br /&gt;Date and Time: March 9, 2026, at 11:20 a.m. ET
&lt;br /&gt;Format: &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fevent.summitcast.com%2Fview%2FmT9poctHDNthc6b89WqVjf%2Fguest_book%3Fsession_id%3DffE6xjDStYAPC5NnkVMYfx&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Fireside+chat&amp;amp;index=2&amp;amp;md5=ad50f00f11531a22c7db9a4eaa9a2687&quot; shape=&quot;rect&quot;&gt;Fireside chat&lt;/a&gt; and 1x1 meetings
&lt;br /&gt;Location: Miami, FL
&lt;br /&gt;

&lt;/li&gt;
&lt;/ul&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
The Citizens Life Sciences Conference
&lt;br /&gt;Date and Time: March 10, 2026, at 12:30 p.m. ET
&lt;br</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</guid>
   <pubDate>Mon, 02 Mar 2026 16:05:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences to Present at Upcoming Investor Conferences in March</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</link>
   <description>
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fsprucebio.com%2F&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d4dbbe0c6efdc7a826517b31902749f9&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at two upcoming investor conferences taking place in March.

&lt;/p&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
Leerink Global Healthcare Conference
&lt;br /&gt;Date and Time: March 9, 2026, at 11:20 a.m. ET
&lt;br /&gt;Format: &lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fevent.summitcast.com%2Fview%2FmT9poctHDNthc6b89WqVjf%2Fguest_book%3Fsession_id%3DffE6xjDStYAPC5NnkVMYfx&amp;amp;esheet=54436800&amp;amp;newsitemid=20260302646693&amp;amp;lan=en-US&amp;amp;anchor=Fireside+chat&amp;amp;index=2&amp;amp;md5=ad50f00f11531a22c7db9a4eaa9a2687&quot; shape=&quot;rect&quot;&gt;Fireside chat&lt;/a&gt; and 1x1 meetings
&lt;br /&gt;Location: Miami, FL
&lt;br /&gt;

&lt;/li&gt;
&lt;/ul&gt;&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
The Citizens Life Sciences Conference
&lt;br /&gt;Date and Time: March 10, 2026, at 12:30 p.m. ET
&lt;br</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+to+Present+at+Upcoming+Investor+Conferences+in+March/26091889.html</guid>
   <pubDate>Mon, 02 Mar 2026 16:05:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Form  SCHEDULE 13G  SPRUCE BIOSCIENCES, INC.               Filed by: INTEGRATED CORE STRATEGIES (US) LLC</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+INTEGRATED+CORE+STRATEGIES+%28US%29+LLC/26052579.html</link>
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   <guid isPermaLink="true">http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+INTEGRATED+CORE+STRATEGIES+%28US%29+LLC/26052579.html</guid>
   <pubDate>Tue, 24 Feb 2026 16:47:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Form  SCHEDULE 13G  SPRUCE BIOSCIENCES, INC.               Filed by: INTEGRATED CORE STRATEGIES (US) LLC</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+INTEGRATED+CORE+STRATEGIES+%28US%29+LLC/26052579.html</link>
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   <guid isPermaLink="true">http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+INTEGRATED+CORE+STRATEGIES+%28US%29+LLC/26052579.html</guid>
   <pubDate>Tue, 24 Feb 2026 16:47:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences, Inc. (SPRB) PT Lowered to $200 at H.C. Wainwright</title>
   <link>http://www.streetinsider.com/Analyst+PT+Change/Spruce+Biosciences%2C+Inc.+%28SPRB%29+PT+Lowered+to+%24200+at+H.C.+Wainwright/26025604.html</link>
   <description>H.C. Wainwright analyst Raghuram Selvaraju lowered the price target on Spruce Biosciences, Inc. (NASDAQ: SPRB) to $200.00  (from $220.00) while maintaining a Buy rating.</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Analyst+PT+Change/Spruce+Biosciences%2C+Inc.+%28SPRB%29+PT+Lowered+to+%24200+at+H.C.+Wainwright/26025604.html</guid>
   <pubDate>Thu, 19 Feb 2026 06:49:32 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Form  SCHEDULE 13D/A  SPRUCE BIOSCIENCES, INC.               Filed by: Carlyle Group Inc.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13DA++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+Carlyle+Group+Inc./26023746.html</link>
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   <guid isPermaLink="true">http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13DA++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+Carlyle+Group+Inc./26023746.html</guid>
   <pubDate>Wed, 18 Feb 2026 17:27:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Form  SCHEDULE 13D/A  SPRUCE BIOSCIENCES, INC.               Filed by: Carlyle Group Inc.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13DA++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+Carlyle+Group+Inc./26023746.html</link>
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   <guid isPermaLink="true">http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13DA++SPRUCE+BIOSCIENCES%2C+INC.+++++++++++++++Filed+by%3A+Carlyle+Group+Inc./26023746.html</guid>
   <pubDate>Wed, 18 Feb 2026 17:27:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences, Inc. (SPRB) PT Lowered to $180 at Citizens</title>
   <link>http://www.streetinsider.com/Analyst+PT+Change/Spruce+Biosciences%2C+Inc.+%28SPRB%29+PT+Lowered+to+%24180+at+Citizens/26023473.html</link>
   <description>Citizens analyst Jonathan Wolleben lowered the price target on Spruce Biosciences, Inc. (NASDAQ: SPRB) to $180.00  (from $259.00) while maintaining a Market Outperform rating.</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Analyst+PT+Change/Spruce+Biosciences%2C+Inc.+%28SPRB%29+PT+Lowered+to+%24180+at+Citizens/26023473.html</guid>
   <pubDate>Wed, 18 Feb 2026 17:10:08 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</guid>
   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.06822034</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">A.50213784</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.08407916</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.20026344</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.37894223</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">SPRB</category>
   	  </item>
  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Press+Releases/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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   	  </item>
  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   	  </item>
  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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  <item>
   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
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&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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   <pubDate>Wed, 18 Feb 2026 07:00:00 -0500</pubDate>
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   <title>Spruce Biosciences Announces Positive Type B Meetings with U.S. FDA for TA-ERT for the Treatment of Sanfilippo Syndrome Type B (MPS IIIB)</title>
   <link>http://www.streetinsider.com/Business+Wire/Spruce+Biosciences+Announces+Positive+Type+B+Meetings+with+U.S.+FDA+for+TA-ERT+for+the+Treatment+of+Sanfilippo+Syndrome+Type+B+%28MPS+IIIB%29/26017591.html</link>
   <description>
&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;Based on FDA Feedback, Company Continues to Advance BLA Submission for TA-ERT Using CSF HS-NRE as &lt;/i&gt;Reasonably Likely Surrogate Endpoint for Accelerated Approval

&lt;/p&gt;&lt;p class=&quot;bwalignc&quot;&gt;
&lt;i&gt;BLA Submission for TA-ERT is Now Anticipated in the Fourth Quarter to Accommodate Drug Product PPQ Requirement&lt;/i&gt;

&lt;/p&gt;
&lt;p&gt;    SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--
&lt;a target=&quot;_blank&quot; rel=&quot;nofollow&quot; href=&quot;https://cts.businesswire.com/ct/CT?id=smartlink&amp;amp;url=https%3A%2F%2Fprotect.checkpoint.com%2Fv2%2Fr01%2F___https%3A%2Fsprucebio.com%2F___.YzJ1OmdpbG1hcnRpbmdyb3VwOmM6bzoyYThiM2I3OTRmZWNlNjEyOWZjMDg2ZWFjNjUzNDk1Yzo3OmNjZjk6ODQxY2FlYzhiNWZjYzY0YWMxYjM0YTMwNTczNjliNDU5YmM5YzhmNDY1NGRlMGEzMmZiZGQ5ZDZkYWVjZThjMzpwOlQ6Rg&amp;amp;esheet=54427625&amp;amp;newsitemid=20260218269143&amp;amp;lan=en-US&amp;amp;anchor=Spruce+Biosciences%2C+Inc.&amp;amp;index=1&amp;amp;md5=d683072463ec528868c4aa9208bdb7b3&quot; shape=&quot;rect&quot;&gt;Spruce Biosciences, Inc.&lt;/a&gt; (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced the successful completion of Type B meetings with the U.S. Food and Drug Administration (FDA or the Agency) regarding its planned upcoming</description>
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