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   <title>Form  S-1        Obsidian Therapeutics,               </title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++S-1++++++++Obsidian+Therapeutics%2C+++++++++++++++/26999026.html</link>
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   <pubDate>Fri, 28 Aug 2026 17:11:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>LifeSci Capital Starts Obsidian Therapeutics (OBX) at Outperform</title>
   <link>http://www.streetinsider.com/New+Coverage/LifeSci+Capital+Starts+Obsidian+Therapeutics+%28OBX%29+at+Outperform/26940203.html</link>
   <description>&lt;p&gt;LifeSci Capital initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Outperform rating and a price target of $43.00.&lt;/p&gt;&lt;p&gt;For an analyst ratings summary and ratings history on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=OBX&quot;&gt;click here&lt;/a&gt;. For more ratings news on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/stock_lookup_news.php?q=OBX&amp;amp;type=analyst&quot;&gt;click here&lt;/a&gt;.&lt;/p&gt;&lt;p&gt;Shares of Obsidian Therapeutics closed at $17.54 yesterday.&lt;/p&gt;</description>
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   <pubDate>Tue, 18 Aug 2026 06:23:44 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  10-Q       Obsidian Therapeutics,    For: Jun 30</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++10-Q+++++++Obsidian+Therapeutics%2C++++For%3A+Jun+30/26931430.html</link>
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   <pubDate>Fri, 14 Aug 2026 16:32:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  8-K/A      Obsidian Therapeutics,    For: Jul 31</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-KA++++++Obsidian+Therapeutics%2C++++For%3A+Jul+31/26931482.html</link>
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   <pubDate>Fri, 14 Aug 2026 16:32:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: Deep Track Capital, LP</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+Deep+Track+Capital%2C+LP/26905494.html</link>
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   <pubDate>Tue, 11 Aug 2026 16:04:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: Atlas Venture Fund X, L.P.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+Atlas+Venture+Fund+X%2C+L.P./26898748.html</link>
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   <pubDate>Mon, 10 Aug 2026 16:44:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: RA CAPITAL MANAGEMENT, L.P.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+RA+CAPITAL+MANAGEMENT%2C+L.P./26898333.html</link>
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   <pubDate>Mon, 10 Aug 2026 16:24:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  SCHEDULE 13G  Obsidian Therapeutics,                 Filed by: Novo Holdings A/S</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++SCHEDULE+13G++Obsidian+Therapeutics%2C+++++++++++++++++Filed+by%3A+Novo+Holdings+AS/26898295.html</link>
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   <pubDate>Mon, 10 Aug 2026 16:22:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>TD Cowen Starts Obsidian Therapeutics (OBX) at Buy</title>
   <link>http://www.streetinsider.com/New+Coverage/TD+Cowen+Starts+Obsidian+Therapeutics+%28OBX%29+at+Buy/26877167.html</link>
   <description>(Updated - August 6, 2026 5:30 AM EDT)

&lt;p&gt;TD Cowen analyst Tyler Van Buren initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Buy rating.&lt;/p&gt;&lt;p&gt;The analyst comments &quot;Amsoki-cel’s next-gen design combining IL-15 regulation with core needle biopsy supports a best-in-class TIL profile. An unprecedented 67% ORR in mCM was achieved with improved safety as IL-2 maintenance is not required. Beyond melanoma, early data and TIL validation support expansion into the large NSCLC market. The world-class management team and our $4B+ peak sales est. support our Buy rating.&quot;&lt;/p&gt;&lt;p&gt;For an analyst ratings summary and ratings history on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=OBX&quot;&gt;click here&lt;/a&gt;. For</description>
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   <pubDate>Thu, 06 Aug 2026 05:30:53 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>TD Cowen Starts Obsidian Therapeutics (OBX) at Buy</title>
   <link>http://www.streetinsider.com/Analyst+Comments/TD+Cowen+Starts+Obsidian+Therapeutics+%28OBX%29+at+Buy/26877167.html</link>
   <description>(Updated - August 6, 2026 5:30 AM EDT)

&lt;p&gt;TD Cowen analyst Tyler Van Buren initiates coverage on Obsidian Therapeutics (NASDAQ: OBX) with a Buy rating.&lt;/p&gt;&lt;p&gt;The analyst comments &quot;Amsoki-cel’s next-gen design combining IL-15 regulation with core needle biopsy supports a best-in-class TIL profile. An unprecedented 67% ORR in mCM was achieved with improved safety as IL-2 maintenance is not required. Beyond melanoma, early data and TIL validation support expansion into the large NSCLC market. The world-class management team and our $4B+ peak sales est. support our Buy rating.&quot;&lt;/p&gt;&lt;p&gt;For an analyst ratings summary and ratings history on Obsidian Therapeutics &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=OBX&quot;&gt;click here&lt;/a&gt;. For</description>
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   <pubDate>Thu, 06 Aug 2026 05:30:53 -0400</pubDate>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: ROSS ROBERT W.</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+ROSS+ROBERT+W./26874299.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:11:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Jagasia Madan</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Jagasia+Madan/26874202.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:09:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Norkunas Matthew</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Norkunas+Matthew/26874208.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:09:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Barrett Peter</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Barrett+Peter/26874165.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:08:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Hagen Heidi</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Hagen+Heidi/26874014.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:06:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Form  4          Obsidian Therapeutics,    For: Aug 03  Filed by: Fardis Maria</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++4++++++++++Obsidian+Therapeutics%2C++++For%3A+Aug+03++Filed+by%3A+Fardis+Maria/26873940.html</link>
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   <pubDate>Wed, 05 Aug 2026 16:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
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   <title>Obsidian enrolls first patient in melanoma registration trial</title>
   <link>http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</link>
   <description>

&lt;p&gt;Obsidian Therapeutics (Nasdaq: OBX) announced the enrollment of the first patient in the registration-enabling cohort of its Phase 1/2 Agni-01 study evaluating amsokigene autoleucel (amsoki-cel) in patients with immune checkpoint inhibitor-resistant advanced or metastatic melanoma.&lt;/p&gt;

&lt;p&gt;The company said it aligned with the FDA on a single-arm trial design intended to support a future Biologics License Application (BLA) submission under an accelerated approval pathway. Key design considerations discussed with the FDA include drug potency assay and manufacturing specifications.&lt;/p&gt;

&lt;p&gt;The registration-enabling cohort follows earlier Phase 1/2 results from the Agni-01 study, in which amsoki-cel showed a 67% objective response rate at the recommended Phase</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:16 -0400</pubDate>
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   <title>Obsidian enrolls first patient in melanoma registration trial</title>
   <link>http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</link>
   <description>

&lt;p&gt;Obsidian Therapeutics (Nasdaq: OBX) announced the enrollment of the first patient in the registration-enabling cohort of its Phase 1/2 Agni-01 study evaluating amsokigene autoleucel (amsoki-cel) in patients with immune checkpoint inhibitor-resistant advanced or metastatic melanoma.&lt;/p&gt;

&lt;p&gt;The company said it aligned with the FDA on a single-arm trial design intended to support a future Biologics License Application (BLA) submission under an accelerated approval pathway. Key design considerations discussed with the FDA include drug potency assay and manufacturing specifications.&lt;/p&gt;

&lt;p&gt;The registration-enabling cohort follows earlier Phase 1/2 results from the Agni-01 study, in which amsoki-cel showed a 67% objective response rate at the recommended Phase</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:16 -0400</pubDate>
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   <title>Obsidian enrolls first patient in melanoma registration trial</title>
   <link>http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</link>
   <description>

&lt;p&gt;Obsidian Therapeutics (Nasdaq: OBX) announced the enrollment of the first patient in the registration-enabling cohort of its Phase 1/2 Agni-01 study evaluating amsokigene autoleucel (amsoki-cel) in patients with immune checkpoint inhibitor-resistant advanced or metastatic melanoma.&lt;/p&gt;

&lt;p&gt;The company said it aligned with the FDA on a single-arm trial design intended to support a future Biologics License Application (BLA) submission under an accelerated approval pathway. Key design considerations discussed with the FDA include drug potency assay and manufacturing specifications.&lt;/p&gt;

&lt;p&gt;The registration-enabling cohort follows earlier Phase 1/2 results from the Agni-01 study, in which amsoki-cel showed a 67% objective response rate at the recommended Phase</description>
   <guid isPermaLink="true">http://www.streetinsider.com/FDA/Obsidian+enrolls+first+patient+in+melanoma+registration+trial/26870136.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:16 -0400</pubDate>
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   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
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   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Press+Releases/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
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   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
   <guid isPermaLink="true">http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</guid>
   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50205019</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00706867</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
      	<category domain="http://rss.financialcontent.com/stocksymbol">A.50205019</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">O.00706867</category>
   	   	<category domain="http://rss.financialcontent.com/stocksymbol">OBX</category>
   	  </item>
  <item>
   <title>Obsidian Therapeutics Announces First Patient Enrolled in the Registration-enabling Cohort of Phase 1/2 Agni-01 Study Evaluating Amsoki-cel (OBX-115) in Advanced Melanoma</title>
   <link>http://www.streetinsider.com/Business+Wire/Obsidian+Therapeutics+Announces+First+Patient+Enrolled+in+the+Registration-enabling+Cohort+of+Phase+12+Agni-01+Study+Evaluating+Amsoki-cel+%28OBX-115%29+in+Advanced+Melanoma/26870127.html</link>
   <description>
&lt;ul class=&quot;bwlistdisc&quot;&gt;
&lt;li&gt;
&lt;i&gt;Following discussions with FDA, Company has decided to pursue a single-arm trial design intended to support future BLA submission&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Initiation of registration-enabling cohort follows positive Phase 1/2 results demonstrating a 67% ORR at RP2D (n=10/15), including 2 complete responses, in patients with difficult-to-treat advanced melanoma&lt;/i&gt;

&lt;/li&gt;
&lt;li&gt;
&lt;i&gt;Topline data from registration-enabling cohort expected by year-end 2027&lt;/i&gt;

&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;    CAMBRIDGE, Mass.--(BUSINESS WIRE)--
Obsidian Therapeutics, Inc. (“Obsidian”) (Nasdaq: OBX), a clinical-stage biopharmaceutical company harnessing novel protein-regulation technology to develop engineered tumor-infiltrating lymphocyte (TIL) cell therapies, today announced the first patient has been enrolled in the registration-enabling cohort of the Phase 1/2 Agni-01 multicenter study of</description>
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   <pubDate>Wed, 05 Aug 2026 07:05:00 -0400</pubDate>
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