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   <title>Form  8-K        MBX Biosciences, Inc.     For: Aug 27</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-K++++++++MBX+Biosciences%2C+Inc.+++++For%3A+Aug+27/26985528.html</link>
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   <pubDate>Thu, 27 Aug 2026 08:34:00 -0400</pubDate>
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   <title>Form  8-K        MBX Biosciences, Inc.     For: Aug 27</title>
   <link>http://www.streetinsider.com/SEC+Filings/Form++8-K++++++++MBX+Biosciences%2C+Inc.+++++For%3A+Aug+27/26985528.html</link>
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   <pubDate>Thu, 27 Aug 2026 08:34:00 -0400</pubDate>
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   <title>MBX Biosciences doses first patient in Phase 3 hypoparathyroidism trial</title>
   <link>http://www.streetinsider.com/FDA/MBX+Biosciences+doses+first+patient+in+Phase+3+hypoparathyroidism+trial/26985091.html</link>
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&lt;p&gt;MBX Biosciences, Inc. (Nasdaq: MBX) announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical trial evaluating once-weekly canvuparatide for the treatment of chronic hypoparathyroidism, according to a company statement dated Aug. 27, 2026.&lt;/p&gt;

&lt;p&gt;The trial (NCT07699471) is a global, multicenter, randomized, double-blind, placebo-controlled study. Approximately 160 adults with chronic hypoparathyroidism will be enrolled and randomized 3:1 to receive canvuparatide or placebo during a 26-week double-blind treatment period, followed by a 78-week open-label extension.&lt;/p&gt;

&lt;p&gt;The 26-week treatment period includes a four-week fixed-dose period at 600 micrograms once weekly, an 18-week individualized dose-titration period of up to 1,600</description>
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   <title>MBX Biosciences doses first patient in Phase 3 hypoparathyroidism trial</title>
   <link>http://www.streetinsider.com/FDA/MBX+Biosciences+doses+first+patient+in+Phase+3+hypoparathyroidism+trial/26985091.html</link>
   <description>

&lt;p&gt;MBX Biosciences, Inc. (Nasdaq: MBX) announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical trial evaluating once-weekly canvuparatide for the treatment of chronic hypoparathyroidism, according to a company statement dated Aug. 27, 2026.&lt;/p&gt;

&lt;p&gt;The trial (NCT07699471) is a global, multicenter, randomized, double-blind, placebo-controlled study. Approximately 160 adults with chronic hypoparathyroidism will be enrolled and randomized 3:1 to receive canvuparatide or placebo during a 26-week double-blind treatment period, followed by a 78-week open-label extension.&lt;/p&gt;

&lt;p&gt;The 26-week treatment period includes a four-week fixed-dose period at 600 micrograms once weekly, an 18-week individualized dose-titration period of up to 1,600</description>
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   <title>MBX Biosciences doses first patient in Phase 3 hypoparathyroidism trial</title>
   <link>http://www.streetinsider.com/FDA/MBX+Biosciences+doses+first+patient+in+Phase+3+hypoparathyroidism+trial/26985091.html</link>
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&lt;p&gt;MBX Biosciences, Inc. (Nasdaq: MBX) announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical trial evaluating once-weekly canvuparatide for the treatment of chronic hypoparathyroidism, according to a company statement dated Aug. 27, 2026.&lt;/p&gt;

&lt;p&gt;The trial (NCT07699471) is a global, multicenter, randomized, double-blind, placebo-controlled study. Approximately 160 adults with chronic hypoparathyroidism will be enrolled and randomized 3:1 to receive canvuparatide or placebo during a 26-week double-blind treatment period, followed by a 78-week open-label extension.&lt;/p&gt;

&lt;p&gt;The 26-week treatment period includes a four-week fixed-dose period at 600 micrograms once weekly, an 18-week individualized dose-titration period of up to 1,600</description>
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   <title>MBX Biosciences doses first patient in Phase 3 hypoparathyroidism trial</title>
   <link>http://www.streetinsider.com/FDA/MBX+Biosciences+doses+first+patient+in+Phase+3+hypoparathyroidism+trial/26985091.html</link>
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&lt;p&gt;MBX Biosciences, Inc. (Nasdaq: MBX) announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical trial evaluating once-weekly canvuparatide for the treatment of chronic hypoparathyroidism, according to a company statement dated Aug. 27, 2026.&lt;/p&gt;

&lt;p&gt;The trial (NCT07699471) is a global, multicenter, randomized, double-blind, placebo-controlled study. Approximately 160 adults with chronic hypoparathyroidism will be enrolled and randomized 3:1 to receive canvuparatide or placebo during a 26-week double-blind treatment period, followed by a 78-week open-label extension.&lt;/p&gt;

&lt;p&gt;The 26-week treatment period includes a four-week fixed-dose period at 600 micrograms once weekly, an 18-week individualized dose-titration period of up to 1,600</description>
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   <title>MBX Biosciences doses first patient in Phase 3 hypoparathyroidism trial</title>
   <link>http://www.streetinsider.com/FDA/MBX+Biosciences+doses+first+patient+in+Phase+3+hypoparathyroidism+trial/26985091.html</link>
   <description>

&lt;p&gt;MBX Biosciences, Inc. (Nasdaq: MBX) announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical trial evaluating once-weekly canvuparatide for the treatment of chronic hypoparathyroidism, according to a company statement dated Aug. 27, 2026.&lt;/p&gt;

&lt;p&gt;The trial (NCT07699471) is a global, multicenter, randomized, double-blind, placebo-controlled study. Approximately 160 adults with chronic hypoparathyroidism will be enrolled and randomized 3:1 to receive canvuparatide or placebo during a 26-week double-blind treatment period, followed by a 78-week open-label extension.&lt;/p&gt;

&lt;p&gt;The 26-week treatment period includes a four-week fixed-dose period at 600 micrograms once weekly, an 18-week individualized dose-titration period of up to 1,600</description>
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   <title>MBX Biosciences doses first patient in Phase 3 hypoparathyroidism trial</title>
   <link>http://www.streetinsider.com/FDA/MBX+Biosciences+doses+first+patient+in+Phase+3+hypoparathyroidism+trial/26985091.html</link>
   <description>

&lt;p&gt;MBX Biosciences, Inc. (Nasdaq: MBX) announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical trial evaluating once-weekly canvuparatide for the treatment of chronic hypoparathyroidism, according to a company statement dated Aug. 27, 2026.&lt;/p&gt;

&lt;p&gt;The trial (NCT07699471) is a global, multicenter, randomized, double-blind, placebo-controlled study. Approximately 160 adults with chronic hypoparathyroidism will be enrolled and randomized 3:1 to receive canvuparatide or placebo during a 26-week double-blind treatment period, followed by a 78-week open-label extension.&lt;/p&gt;

&lt;p&gt;The 26-week treatment period includes a four-week fixed-dose period at 600 micrograms once weekly, an 18-week individualized dose-titration period of up to 1,600</description>
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   <title>MBX Biosciences Announces First Patient Dosed in Pivotal Phase 3 oPTimize Trial of Once-Weekly Canvuparatide in Adults with Hypoparathyroidism</title>
   <link>http://www.streetinsider.com/Press+Releases/MBX+Biosciences+Announces+First+Patient+Dosed+in+Pivotal+Phase+3+oPTimize+Trial+of+Once-Weekly+Canvuparatide+in+Adults+with+Hypoparathyroidism/26984966.html</link>
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&lt;p align=&quot;center&quot;&gt;&lt;em&gt;Pivotal Phase 3 oPTimize trial design builds on positive Phase 2 Avail™ results and durable &lt;br/&gt;one-year clinical benefit&lt;/em&gt;&lt;/p&gt;  &lt;p align=&quot;center&quot;&gt;&lt;em&gt;Global registrational trial to enroll approximately 160 adults with HP to support once-weekly &lt;br/&gt;canvuparatide’s potential as a best-in-class PTH replacement therapy&lt;/em&gt;&lt;/p&gt;  &lt;p&gt;CARMEL, Ind., and BURLINGTON, Mass., Aug.  27, 2026  (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical</description>
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   <title>MBX Biosciences Announces First Patient Dosed in Pivotal Phase 3 oPTimize Trial of Once-Weekly Canvuparatide in Adults with Hypoparathyroidism</title>
   <link>http://www.streetinsider.com/Press+Releases/MBX+Biosciences+Announces+First+Patient+Dosed+in+Pivotal+Phase+3+oPTimize+Trial+of+Once-Weekly+Canvuparatide+in+Adults+with+Hypoparathyroidism/26984966.html</link>
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&lt;p align=&quot;center&quot;&gt;&lt;em&gt;Pivotal Phase 3 oPTimize trial design builds on positive Phase 2 Avail™ results and durable &lt;br/&gt;one-year clinical benefit&lt;/em&gt;&lt;/p&gt;  &lt;p align=&quot;center&quot;&gt;&lt;em&gt;Global registrational trial to enroll approximately 160 adults with HP to support once-weekly &lt;br/&gt;canvuparatide’s potential as a best-in-class PTH replacement therapy&lt;/em&gt;&lt;/p&gt;  &lt;p&gt;CARMEL, Ind., and BURLINGTON, Mass., Aug.  27, 2026  (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical</description>
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   <title>MBX Biosciences Announces First Patient Dosed in Pivotal Phase 3 oPTimize Trial of Once-Weekly Canvuparatide in Adults with Hypoparathyroidism</title>
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&lt;p align=&quot;center&quot;&gt;&lt;em&gt;Pivotal Phase 3 oPTimize trial design builds on positive Phase 2 Avail™ results and durable &lt;br/&gt;one-year clinical benefit&lt;/em&gt;&lt;/p&gt;  &lt;p align=&quot;center&quot;&gt;&lt;em&gt;Global registrational trial to enroll approximately 160 adults with HP to support once-weekly &lt;br/&gt;canvuparatide’s potential as a best-in-class PTH replacement therapy&lt;/em&gt;&lt;/p&gt;  &lt;p&gt;CARMEL, Ind., and BURLINGTON, Mass., Aug.  27, 2026  (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical</description>
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   <title>MBX Biosciences Announces First Patient Dosed in Pivotal Phase 3 oPTimize Trial of Once-Weekly Canvuparatide in Adults with Hypoparathyroidism</title>
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&lt;p align=&quot;center&quot;&gt;&lt;em&gt;Pivotal Phase 3 oPTimize trial design builds on positive Phase 2 Avail™ results and durable &lt;br/&gt;one-year clinical benefit&lt;/em&gt;&lt;/p&gt;  &lt;p align=&quot;center&quot;&gt;&lt;em&gt;Global registrational trial to enroll approximately 160 adults with HP to support once-weekly &lt;br/&gt;canvuparatide’s potential as a best-in-class PTH replacement therapy&lt;/em&gt;&lt;/p&gt;  &lt;p&gt;CARMEL, Ind., and BURLINGTON, Mass., Aug.  27, 2026  (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical</description>
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   <title>MBX Biosciences Announces First Patient Dosed in Pivotal Phase 3 oPTimize Trial of Once-Weekly Canvuparatide in Adults with Hypoparathyroidism</title>
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&lt;p align=&quot;center&quot;&gt;&lt;em&gt;Pivotal Phase 3 oPTimize trial design builds on positive Phase 2 Avail™ results and durable &lt;br/&gt;one-year clinical benefit&lt;/em&gt;&lt;/p&gt;  &lt;p align=&quot;center&quot;&gt;&lt;em&gt;Global registrational trial to enroll approximately 160 adults with HP to support once-weekly &lt;br/&gt;canvuparatide’s potential as a best-in-class PTH replacement therapy&lt;/em&gt;&lt;/p&gt;  &lt;p&gt;CARMEL, Ind., and BURLINGTON, Mass., Aug.  27, 2026  (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical</description>
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   <title>MBX Biosciences Announces First Patient Dosed in Pivotal Phase 3 oPTimize Trial of Once-Weekly Canvuparatide in Adults with Hypoparathyroidism</title>
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&lt;p align=&quot;center&quot;&gt;&lt;em&gt;Pivotal Phase 3 oPTimize trial design builds on positive Phase 2 Avail™ results and durable &lt;br/&gt;one-year clinical benefit&lt;/em&gt;&lt;/p&gt;  &lt;p align=&quot;center&quot;&gt;&lt;em&gt;Global registrational trial to enroll approximately 160 adults with HP to support once-weekly &lt;br/&gt;canvuparatide’s potential as a best-in-class PTH replacement therapy&lt;/em&gt;&lt;/p&gt;  &lt;p&gt;CARMEL, Ind., and BURLINGTON, Mass., Aug.  27, 2026  (GLOBE NEWSWIRE) -- MBX Biosciences, Inc. (Nasdaq: MBX), a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders, today announced that the first patient has been dosed in its pivotal Phase 3 oPTimize clinical</description>
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   <title>JPMorgan Reinstates MBX Biosciences Inc (MBX) at Overweight</title>
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   <description>&lt;p&gt;JPMorgan analyst Jessica Fye reinstates coverage on MBX Biosciences Inc (NASDAQ: MBX) with a Overweight rating and a price target of $88.00.&lt;/p&gt;
&lt;p&gt;For an analyst ratings summary and ratings history on MBX Biosciences Inc &lt;a href=&quot;http://www.streetinsider.com/rating_history.php?q=MBX&quot;&gt;click here&lt;/a&gt;. For more ratings news on MBX Biosciences Inc &lt;a href=&quot;http://www.streetinsider.com/stock_lookup_news.php?q=MBX&amp;amp;type=analyst&quot;&gt;click here&lt;/a&gt;.&lt;/p&gt;
&lt;p&gt;Shares of MBX Biosciences Inc closed at $66.35 yesterday.&lt;/p&gt;</description>
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