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GeneDx Reports Second Quarter 2026 Financial Results

August 3, 2026 4:05 PM

GAITHERSBURG, Md.--(BUSINESS WIRE)-- GeneDx Holdings Corp. (Nasdaq: WGS), the leader in rare disease diagnosis and improving health through the power of genomic data, today reported its financial results for the second quarter of 2026.

“Our team’s unwavering focus and agility drove a strong second quarter. By delivering healthy revenue, volume, and gross margin growth, we successfully navigated our return to profitability,” said Katherine Stueland, CEO of GeneDx. “We are managing the transition to genome testing, making progress on each of our key imperatives — optimizing unit economics, growing utilization, and delivering the best products at unmatched scale — while continuing to extend our industry-leading position in both exome and genome testing to reach as many patients and families as soon as possible.”

Second Quarter 2026 Financial Results (Unaudited)(1)

Revenue

Exome and genome volume

Gross margin

Operating expenses

Net income

Cash position

(1)

Adjusted gross margin, adjusted total operating expenses and adjusted net income are non-GAAP financial measures. See appendix for a reconciliation of GAAP to non-GAAP figures presented.

GeneDx 2026 Guidance

GeneDx has reaffirmed its full year 2026 guidance and has provided guidance for the third quarter of 2026. Management expects GeneDx to deliver:

Metric

Full Year 2026 Guidance

Third Quarter 2026 Guidance

Revenue

$475 to $490 million

$122 to $124 million

Exome and genome volume

At least 30% growth

33,200 tests

Exome and genome revenue

At least 20% growth

$110 to $112 million

Adjusted gross margin

Approximately 70%

Approximately 70%

Adjusted net income

Positive

Approximately $2 million

Second Quarter 2026 and Recent Business Highlights

Strategic Expansion and Market Leadership

Expanded Coverage for Exome and Genome

Innovation and Clinical Leadership

Webcast and Conference Call Details

GeneDx will host a conference call today, August 3, 2026, at 4:30 p.m. Eastern Time. Investors interested in listening to the conference call are required to register online. A live and archived webcast of the event will be available on the “Events” section of the GeneDx investor relations website at https://ir.genedx.com/.

Non-GAAP Financial Measures

GeneDx believes non-GAAP measures are useful in evaluating its operating performance. GeneDx uses this supplemental information to evaluate its ongoing operations and for internal planning and forecasting purposes. GeneDx believes that non-GAAP financial information, when taken collectively with its GAAP financial information, may be helpful to investors because it provides consistency and comparability with past financial performance. However, non-GAAP financial information is presented for supplemental informational purposes only, has limitations as an analytical tool, and should not be considered in isolation or as a substitute for financial information presented in accordance with GAAP. Reconciliations of non-GAAP financial measures to the most directly comparable financial results as determined in accordance with GAAP are included at the end of this press release following the accompanying financial data. We define non-GAAP financial measures as GAAP measures, excluding certain items such as stock-based compensation expense, depreciation and amortization, restructuring costs, changes in the fair value of financial liabilities, non-core lease costs, and other expenses that the Company believes are not indicative of its ongoing operations. A reconciliation of non-GAAP guidance measures to corresponding GAAP measures is not available on a forward-looking basis without unreasonable effort due to the uncertainty of expenses that may be incurred in the future. Investors are encouraged to review the related GAAP financial measures and the reconciliation of these non-GAAP financial measures to their most directly comparable GAAP financial measures and not rely on any single financial measure to evaluate our business.

Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995, including statements regarding our future performance and our market opportunity, including our expectations for full year and third quarter 2026 revenue, exome and genome revenue and test volumes, adjusted gross margin and adjusted net income. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) our ability to implement business plans, goals and forecasts, and identify and realize additional opportunities, (ii) the risk of downturns and a changing regulatory landscape in the highly competitive healthcare industry, (iii) the size and growth of the market in which we operate, and (iv) future expansion of insurance coverage for exome and genome testing. The foregoing list of factors is not exhaustive. You should carefully consider the foregoing factors and the other risks and uncertainties described in the “Risk Factors” section of our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the U.S. Securities and Exchange Commission (the “SEC”) on February 23, 2026, our Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2026, filed with the SEC on May 4, 2026, our Quarterly Report on Form 10-Q for the fiscal quarter ended June 30, 2026, filed with the SEC on August 3, 2026, and other documents filed by us from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and we assume no obligation and do not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. We do not give any assurance that we will achieve our expectations.

About GeneDx

GeneDx’s (Nasdaq: WGS) mission is to empower everyone to live their healthiest life through genomics. GeneDx combines unmatched clinical expertise, advanced technology, and the power of GeneDx Infinity™ – the world’s largest rare disease genomic dataset. This unparalleled foundation powers GeneDx’s ExomeDx™ and GenomeDx™ tests – ranked #1 by expert geneticists and granted FDA Breakthrough Device designation – enabling clinicians to deliver precise, fast, and actionable diagnoses. GeneDx Infinity also fuels discovery for biopharma, with the most powerful AI-driven genomic intelligence. A genomics pioneer over the last 25 years, diagnosing more than 4,800 genetic diseases and publishing more than 1,100 research publications, GeneDx is building the network that will drive the future of genomic precision medicine. For more information, visit genedx.com and connect with us on LinkedIn, Facebook, and Instagram.

Volume & Revenue

2Q26

1Q26

4Q25

3Q25

2Q25

Volumes

Whole exome, whole genome

30,785

27,488

27,761

25,702

23,246

Other panels

32,057

27,729

31,281

34,514

34,510

Total

62,842

55,217

59,042

60,216

57,756

Revenue ($ millions)

Whole exome, whole genome

$

100.3

$

90.6

$

104.0

$

98.9

$

86.0

Other panels

11.6

10.7

13.3

14.6

14.1

Data information

2.3

0.8

2.6

1.5

2.0

Software and interpretation services

0.2

0.2

1.1

1.7

0.6

Total

$

114.4

$

102.3

$

121.0

$

116.7

$

102.7

Unaudited Select Financial Information

Three months ended June 30, 2026

Reported

Depreciation and amortization

Stock-based compensation

Restructuring costs

Change in FV of financial liabilities

Other(2)

Adjusted

Diagnostic test revenue

$

111,886

$

$

$

$

$

$

111,886

Other revenue

2,554

2,554

Total revenue

114,440

114,440

Cost of services

36,202

(1,726

)

(561

)

(47

)

33,868

Gross profit

78,238

1,726

561

47

80,572

Gross margin

68.4

%

70.4

%

Research and development

19,656

(271

)

(1,387

)

(1,036

)

16,962

Selling, general and administrative

76,037

(4,717

)

(4,394

)

(2,212

)

(1,353

)

63,361

(Loss) income from operations

(17,455

)

6,714

6,342

3,295

1,353

249

Interest expense, net

(1,185

)

1,185

Other income (expense), net

382

(220

)

162

Income tax benefit

518

(518

)

Net (loss) income

$

(17,740

)

$

6,714

$

6,342

$

3,295

$

(220

)

$

2,020

$

411

Basic (loss) earnings per share(1)

$

(0.60

)

$

0.01

Diluted (loss) earnings per share(1)

$

(0.60

)

$

0.01

Three months ended June 30, 2025

Reported

Depreciation and

amortization

Stock-based

compensation

Restructuring costs

Change in FV of

financial liabilities

Other(2)

Adjusted

Diagnostic test revenue

$

100,100

$

$

$

$

$

$

100,100

Other revenue

2,592

2,592

Total revenue

102,692

102,692

Cost of services

31,790

(1,389

)

(193

)

30,208

Gross profit

70,902

1,389

193

72,484

Gross margin

69.0

%

70.6

%

Research and development

15,079

(209

)

(1,422

)

13,448

Selling, general and administrative

46,863

(4,593

)

(6,198

)

(73

)

6,937

42,936

Income from operations

8,960

6,191

7,813

73

(6,937

)

16,100

Interest expense, net

(817

)

817

Other income (expense), net

2,420

(2,181

)

49

288

Income tax benefit

246

(246

)

Net income

$

10,809

$

6,191

$

7,813

$

73

$

(2,181

)

$

(6,317

)

$

16,388

Basic earnings per share(1)

$

0.38

$

0.57

Diluted earnings per share(1)

$

0.36

$

0.55

(1)

Basic and diluted reported loss per share and Basic adjusted earnings per share are calculated based on 29,710,139 weighted average shares outstanding and Diluted adjusted earnings per share are calculated based on 30,144,132 weighted average shares outstanding for the three months ended June 30, 2026. Basic and diluted earnings per share are calculated based on 28,579,704 and 29,753,933 weighted average shares outstanding for the three months ended June 30, 2025, respectively.

(2)

Other represents interest expense, net, income tax benefit and non-core lease costs for all periods presented. For the three months ended June 30, 2026, Other also includes costs related to legal reserves. For the three months ended June 30, 2025, Other includes transaction costs incurred in connection with the acquisition of Fabric Genomics and a sales-and-use tax refund.

Unaudited Select Financial Information

Three months ended March 31, 2026

Reported

Depreciation and amortization

Stock-based compensation

Restructuring costs

Change in FV of financial liabilities

Extinguishment

of debt

Other(2)

Adjusted

Diagnostic test revenue

$

101,299

$

$

$

$

$

$

$

101,299

Other revenue

955

955

Total revenue

102,254

102,254

Cost of services

34,043

(1,462

)

(380

)

32,201

Gross profit

68,211

1,462

380

70,053

Gross margin

66.7

%

68.5

%

Research and development

19,804

(224

)

(1,406

)

(224

)

17,950

Selling, general and administrative

74,591

(5,123

)

(7,210

)

(215

)

(1,916

)

60,127

Impairment loss

31,287

(31,287

)

Loss from operations

(57,471

)

6,809

8,996

439

33,203

(8,024

)

Interest expense, net

(717

)

717

Other (expense) income, net

(4,231

)

(2,540

)

6,565

(206

)

Income tax expense

(897

)

897

Net loss

$

(63,316

)

$

6,809

$

8,996

$

439

$

(2,540

)

$

6,565

$

34,817

$

(8,230

)

Basic and diluted loss per share(1)

$

(2.16

)

$

(0.28

)

(1)

Basic and diluted loss per share are calculated based on 29,335,126 weighted average shares outstanding for the three months ended March 31, 2026.

(2)

For the three months ended March 31, 2026, Other represents interest expense, net, income tax expense and non-core lease costs, costs related to legal reserves, and impairment of goodwill and intangible assets associated with the Fabric Genomics acquisition.

GeneDx Holdings Corp.

Condensed Consolidated Balance Sheets

(in thousands, except share and per share amounts)

June 30, 2026 (Unaudited)

December 31, 2025

Assets:

Current assets:

Cash and cash equivalents

$

60,317

$

104,997

Marketable securities

72,231

66,285

Accounts receivable

83,610

74,370

Inventory, net

17,820

13,951

Prepaid expenses and other current assets

12,382

8,685

Total current assets

246,360

268,288

Operating lease right-of-use assets

33,535

23,412

Property and equipment, net

54,316

45,693

Goodwill

1,641

13,520

Intangible assets, net

141,350

168,481

Other assets(1)

4,284

4,316

Total assets

$

481,486

$

523,710

Liabilities and Stockholders’ Equity:

Current liabilities:

Accounts payable and accrued expenses

$

42,091

$

57,645

Short-term lease liabilities

5,709

4,404

Other current liabilities

26,828

46,859

Total current liabilities

74,628

108,908

Long-term debt, net of current portion

96,836

48,176

Long-term lease liabilities

64,857

56,046

Other liabilities

71

1,641

Deferred taxes

873

757

Total liabilities

237,265

215,528

Stockholders’ Equity:

Preferred stock

Class A common stock

3

3

Additional paid-in capital

1,698,427

1,680,738

Accumulated deficit

(1,454,551

)

(1,373,495

)

Accumulated other comprehensive income

342

936

Total stockholders’ equity

244,221

308,182

Total liabilities and stockholders’ equity

$

481,486

$

523,710

(1) Other assets includes $1.0 million of restricted cash as of both June 30, 2026 and December 31, 2025.

GeneDx Holdings Corp.

Condensed Consolidated Statements of Operations (Unaudited)

(in thousands, except share and per share amounts)

Three months ended June 30,

Six months ended June 30,

2026

2025

2026

2025

Revenue

Diagnostic test revenue

$

111,886

$

100,100

$

213,185

$

185,859

Other revenue

2,554

2,592

3,509

3,948

Total revenue

114,440

102,692

216,694

189,807

Cost of services

36,202

31,790

70,245

60,429

Gross profit

78,238

70,902

146,449

129,378

Research and development

19,656

15,079

39,460

27,656

Selling, general and administrative

76,037

46,863

150,628

97,313

Impairment loss

31,287

(Loss) income from operations

(17,455

)

8,960

(74,926

)

4,409

Non-operating (expense) income, net

Change in fair value of financial liabilities

220

2,181

2,760

1,081

Interest expense, net

(1,185

)

(817

)

(1,902

)

(1,457

)

Loss on extinguishment of debt

(6,565

)

Other income (expense), net

162

239

(44

)

448

Total non-operating (expense) income, net

(803

)

1,603

(5,751

)

72

(Loss) income before income taxes

(18,258

)

10,563

(80,677

)

4,481

Income tax benefit (expense)

518

246

(379

)

(201

)

Net (loss) income

$

(17,740

)

$

10,809

$

(81,056

)

$

4,280

Weighted-average shares outstanding of Class A common stock - Basic

29,710,139

28,579,704

29,523,669

28,365,018

Basic (loss) earnings per share, Class A common stock

$

(0.60

)

$

0.38

$

(2.75

)

$

0.15

Weighted-average shares outstanding of Class A common stock - Diluted

29,710,139

29,753,933

29,523,669

29,642,555

Diluted (loss) earnings per share, Class A common stock

$

(0.60

)

$

0.36

$

(2.75

)

$

0.14

GeneDx Holdings Corp.

Condensed Consolidated Statements of Cash Flows (Unaudited)

(in thousands)

Six months ended June 30,

2026

2025

Operating activities

Net (loss) income

$

(81,056

)

$

4,280

Adjustments to reconcile net loss to net cash (used in) provided by operating activities:

Depreciation and amortization expense

13,523

11,869

Stock-based compensation expense

15,338

11,796

Change in fair value of financial liabilities

(2,760

)

(1,081

)

Deferred tax expense

379

202

Change in third party payor reserves

(1,022

)

5,014

Loss on extinguishment of debt

6,565

Impairment loss

31,287

Other

2,157

1,510

Change in operating assets and liabilities:

Accounts receivable

(9,240

)

(9,889

)

Inventory

(3,973

)

(1,404

)

Accounts payable and accrued expenses

(12,566

)

7,199

Other assets and liabilities

(20,021

)

(8,894

)

Net cash (used in) provided by operating activities

(61,389

)

20,602

Investing activities

Acquisition of business, net of cash acquired

(33,195

)

Purchases of marketable securities

(29,065

)

(30,770

)

Proceeds from sales of marketable securities

2,272

Proceeds from maturities of marketable securities

20,475

26,705

Purchases of property and equipment and development of internal-use software

(16,567

)

(8,498

)

Net cash used in investing activities

(22,885

)

(45,758

)

Financing activities

Proceeds from long term debt, net of issuance costs

96,699

Proceeds from offerings, net of issuance costs

13,766

Proceeds from issuance of common stock from subscription agreements

476

Proceeds from issuance of common stock pursuant to employee stock purchase plan

1,793

1,262

Exercise of stock options

58

800

Repayment of long-term debt, including prepayment penalty - Perceptive

(54,000

)

Repayment and principal payments for long-term debt - DECD

(4,447

)

(602

)

Finance lease principal payments

(984

)

(1,162

)

Net cash provided by financing activities

39,595

14,064

Net decrease in cash, cash equivalents and restricted cash

(44,679

)

(11,092

)

Cash, cash equivalents and restricted cash, at beginning of period

105,989

86,202

Cash, cash equivalents and restricted cash, at end of period (1)

$

61,310

$

75,110

Supplemental disclosures of cash flow information

Cash paid for interest

$

3,813

$

3,210

Cash paid for taxes

$

2,221

$

920

Lease liability from obtaining right-of-use asset

$

12,086

$

Purchases of property and equipment in accounts payable and accrued expenses

$

3,154

$

5,752

(1) Cash, cash equivalents and restricted cash as of June 30, 2026 excludes marketable securities of $72.2 million.

Investor Relations Contact:

[email protected]

Media Contact:

[email protected]

Source: GeneDx

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