Form S-8 POS Esperion Therapeutics,
As filed with the Securities and Exchange Commission on July 13, 2026
Registration No. 333-289575
Registration No. 333-281486
Registration No. 333-274183
Registration No. 333-273555
Registration No. 333-265247
Registration No. 333-262881
Registration No. 333-253414
Registration No. 333-243757
Registration No. 333-236712
Registration No. 333-228994
Registration No. 333-223105
Registration No. 333-218084
Registration No. 333-216169
Registration No. 333-208702
Registration No. 333-206180
Registration No. 333-201378
Registration No. 333-194536
Registration No. 333-189738
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
Post-Effective Amendment No. 1 to:
Form S-8 Registration Statement No. 333-289575
Form S-8 Registration Statement No. 333-281486
Form S-8 Registration Statement No. 333-274183
Form S-8 Registration Statement No. 333-273555
Form S-8 Registration Statement No. 333-265247
Form S-8 Registration Statement No. 333-262881
Form S-8 Registration Statement No. 333-253414
Form S-8 Registration Statement No. 333-243757
Form S-8 Registration Statement No. 333-236712
Form S-8 Registration Statement No. 333-228994
Form S-8 Registration Statement No. 333-223105
Form S-8 Registration Statement No. 333-218084
Form S-8 Registration Statement No. 333-216169
Form S-8 Registration Statement No. 333-208702
Form S-8 Registration Statement No. 333-206180
Form S-8 Registration Statement No. 333-201378
Form S-8 Registration Statement No. 333-194536
Form S-8 Registration Statement No. 333-189738
UNDER
THE SECURITIES ACT OF 1933
ESPERION THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
| Delaware | 26-1870780 | |
| (State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
3891 Ranchero Drive, Suite 150
Ann Arbor, MI 48108
(Address of Principal Executive Offices) (Zip Code)
2022 STOCK OPTION AND INCENTIVE PLAN, AS AMENDED
2020 EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED
2017 INDUCEMENT EQUITY PLAN, AS AMENDED
AMENDED AND RESTATED 2013 STOCK OPTION AND INCENTIVE PLAN
2013 STOCK OPTION AND INCENTIVE PLAN
2008 INCENTIVE STOCK OPTION AND RESTRICTED STOCK PLAN
(Full titles of the plans)
Sheldon L. Koenig
Chief Executive Officer and President
Esperion Therapeutics, Inc.
3891 Ranchero Drive, Suite 150
Ann Arbor, MI 48108
(734) 887-3903
(Name, address, including zip code, and telephone number, including area code, of agent for service)
Copies to:
David D’Urso
Adam Cromie
Sidley Austin LLP
787 Seventh Avenue
New York, NY 10019
(212) 839-5300
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
| Large accelerated filer | ☐ | Accelerated filer | ☒ |
| Non-accelerated filer | ☐ | Smaller reporting company | ☒ |
| Emerging growth company | ☐ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨
DEREGISTRATION OF SECURITIES
These post-effective amendments (the “Post-Effective Amendments”), filed by Esperion Therapeutics, Inc., a Delaware corporation (the “Company”), remove from registration as of the date hereof all shares of common stock, par value $0.001 per share, of the Company (the “Common Stock”) previously registered under the following Registration Statements on Form S-8 filed by the Company (the “Registration Statements”) with the U.S. Securities and Exchange Commission (the “SEC”) pertaining to the registration of shares of Common Stock.
| · | Registration No. 333-289575, which was previously filed with the SEC on August 13, 2025, registering 6,250,000 shares of Common Stock under the 2022 Stock Option and Incentive Plan, as amended; |
| · | Registration No. 333-281486, which was previously filed with the SEC on August 12, 2024, registering (i) 6,250,000 shares of Common Stock under the 2022 Stock Option and Incentive Plan, as amended, and (ii) 6,175,000 shares of Common Stock under the 2020 Employee Stock Purchase Plan, as amended; |
| · | Registration No. 333-274183, which was previously filed with the SEC on August 24, 2023, registering 1,500,000 shares of Common Stock under the 2017 Inducement Equity Plan, as amended; |
| · | Registration No. 333-273555, which was previously filed with the SEC on August 1, 2023, registering 6,250,000 shares of Common Stock under the 2022 Stock Option and Incentive Plan, as amended; |
| · | Registration No. 333-265247, which was previously filed with the SEC on May 26, 2022, registering 4,400,000 shares of Common Stock under the 2022 Stock Option and Incentive Plan; |
| · | Registration No. 333-262881, which was previously filed with the SEC on February 22, 2022, registering 1,571,842 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-253414, which was previously filed with the SEC on February 23, 2021, registering 697,759 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-243757, which was previously filed with the SEC on August 10, 2020, registering 825,000 shares of Common Stock under the 2020 Employee Stock Purchase Plan, as amended; |
| · | Registration No. 333-236712, which was previously filed with the SEC on February 27, 2020, registering (i) 687,447 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan and (ii) 400,000 shares of Common Stock under the 2017 Inducement Equity Plan; |
| · | Registration No. 333-228994, which was previously filed with the SEC on December 21, 2018, registering 670,621 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-223105, which was previously filed with the SEC on February 20, 2018, registering 657,616 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-218084, which was previously filed with the SEC on May 18, 2017, registering 750,000 shares of Common Stock under the 2017 Inducement Equity Plan; |
| · | Registration No. 333-216169, which was previously filed with the SEC on February 22, 2017, registering 563,885 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-208702, which was previously filed with the SEC on December 22, 2015, registering 562,973 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-206180, which was previously filed with the SEC on August 6, 2015, registering 923,622 shares of Common Stock under the Amended and Restated 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-201378, which was previously filed with the SEC on January 6, 2015, registering 508,821 shares of Common Stock under the 2013 Stock Option and Incentive Plan; |
| · | Registration No. 333-194536, which was previously filed with the SEC on March 13, 2014, registering 383,935 shares of Common Stock under the 2013 Stock Option and Incentive Plan; and |
| · | Registration No. 333-189738, which was previously filed with the SEC on July 1, 2013, registering (i) 668,816 shares of Common Stock under the 2008 Incentive Stock Option and Restricted Stock Plan and (ii) 1,154,129 shares of Common Stock under the 2013 Stock Option and Incentive Plan. |
On May 1, 2026, the Company entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Essence Parent Inc., a Delaware corporation (“Parent”), and Essence MergerCo Inc., a Delaware corporation and wholly owned subsidiary of Parent (“MergerCo”), which provides for the merger of MergerCo with and into the Company with the Company continuing as the surviving corporation and a wholly owned subsidiary of Parent (the “Merger”). The Merger became effective on July 13, 2026, pursuant to a Certificate of Merger filed with the Secretary of State of the State of Delaware.
As a result of the Merger, the Company has terminated all offerings of the Company’s securities registered pursuant to its existing registration statements under the Securities Act of 1933, as amended, including the Registration Statements. The Company, by filing these Post-Effective Amendments, hereby terminates the effectiveness of the Registration Statements and removes from registration any and all plan interests and any and all securities registered for issuance under the Registration Statements that remain unsold as of the date hereof. This filing is made in accordance with an undertaking made by the Company in each of the Registration Statements to remove from registration by means of a post-effective amendment any securities that had been registered for issuance that remain unsold at the termination of the offering.
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused these Post-Effective Amendments to the Registration Statements on Form S-8 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Ann Arbor, State of Michigan, on this July 13, 2026.
| ESPERION THERAPEUTICS, INC. | |||
| By: | /s/ Sheldon L. Koenig | ||
| Name: | Sheldon L. Koenig | ||
| Title: | Chief Executive Officer and President | ||
No other person is required to sign these Post-Effective Amendments in reliance upon Rule 478 under the Securities Act of 1933, as amended.
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