Phio Pharmaceuticals (PHIO) Presenting Data on PH-894

PH-894: Potent and Specific Silencing of BRD4 in NK Cells

Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biotechnology company creating new pathways towards a cancer-free future by using its INTASYL^® siRNA gene silencing technology designed to make the body's immune cells more effective in killing cancer cells. Phio announced today that it is presenting data about its INTASYL compound PH-894 at the American Society of Gene & Cell Therapy's (ASGCT's) 2024 Advancing Gene and Cell Therapies for Cancer conference. The conference will take place virtually and at the Wyndham Hotel, Philadelphia Historic District, Philadelphia, PA.

Phio's presentation will focus on how its INTASYL compound PH-894 provides a promising approach for improving the functionality and cytotoxicity of Natural Killer (NK) cells, the body's first line of defense against cancer:

• PH-894 treatment leads to potent and specific silencing of BRD4 in NK cells, without affecting cell viability.
• Incorporation of PH-894 during ex vivo NK cell expansion protocols boosts NK cell numbers by enhancing their proliferation, potentially yielding more effective therapeutic doses.
• PH-894 treatment decreases the expression of CD94, an inhibitory receptor, allowing for improved cytotoxic potential by limiting NK cell inhibition.
• PH-894 may improve NK cell efficacy in adoptive cell therapies by boosting their immune capabilities.

The INTASYL compound PH-894 serves as a foundation for future NK cell-based immunotherapies and supports further exploration of BRD4 as a target in NK cell-based immunotherapies.

Presentation Details are as follows:

You May Also Be Interested In

• Trump: Iran Will Pay For US Forces Killings Many Times Over
• Vertical Aerospace completes eVTOL transition flight at Farnborough
• Goldman Sachs on IREN Ltd. (IREN): 'We estimate that the newly announced contracts represent an additional ~$1 bn'